New synthetic strategies for the stereocontrolled synthesis of substituted ‘skipped’ diepoxides

New synthetic strategies for the stereocontrolled synthesis of substituted "skipped" diepoxides.

This report describes a number of new synthetic approaches towards methyl-substituted mono- and diepoxy alcohols that serve as substrates for endo-selective epoxide-opening cascades. The key transformations involve the manipulation of alkynes. Highlighted are the directed methylmetalation of bishomopropargylic alcohols, the bromoallylation of alkynes, and Pd-catalyzed cross-coupling between an ...

Tetrabutylammonium bromide-Cesium carbonate: new reagent system for the synthesis of substituted pyridines at room temperature

The highly substituted pyridine derivatives are found to exhibit diverse pharmacological activities. They are also emerged as potential medicinal leads in developing therapeutic agents for the treatment of various diseases. In this work, a series of 2-amino-3,5-dicarbonitrile-6-thio-pyridine derivatives have been synthesized at room temperature via one-pot, multi-component reaction of various a...

Fe3O4@SiO2@Propyl-ANDSA: A New Catalyst for the Synthesis of Substituted Pyrroles

Substituted pyrroles are an essential class of heterocyclic compounds. In this research, an efficient and eco-friendly method has been developed for the synthesis of pyrrole derivatives from the reaction of 2,5-hexanedione and primary amines. Magnetic nanoparticles supported on functionalized. 7-aminonaphthalene-1,3-disulfonic acid-functionalized. silica (Fe3O4@SiO2@Propyl–ANDSA) has been inves...

nano-rods zno as an efficient catalyst for the synthesis of chromene phosphonates, direct amidation and formylation of amines

چکیده ندارد.

Stereocontrolled total synthesis of (+)-UCS1025A.